Impulsive Vaccination SEIR Model with Nonlinear Incidence Rate and Time Delay

This paper aims to discuss the delay epidemic model with vertical transmission, constant input, and nonlinear incidence. Some sufficient conditions are given to guarantee the existence and global attractiveness of the infection-free periodic solution and the uniform persistence of the addressed model with time delay. Finally, a numerical example is given to demonstrate the effectiveness of the proposed results

Vestibular dysfunction in Parkinson’s disease: a neglected topic

Dizziness and postural instability are frequently observed symptoms in patient with Parkinson’s disease (PD), potentially linked to vestibular dysfunction. Despite their significant impact on quality of life, these symptoms are often overlooked and undertreated in clinical practice. This review aims to summarize symptoms associated with vestibular dysfunction in patients with PD and discusses vestibular-targeted therapies for managing non-specific dizziness and related symptoms. We conducted searches in PubMed and Web of Science using keywords related to vestibular dysfunction, Parkinson’s disease, dizziness, and postural instability, alongside the reference lists of relevant articles. The available evidence suggests the prevalence of vestibular dysfunction-related symptoms in patients with PD and supports the idea that vestibular-targeted therapies may be effective in improving PD symptoms

Genetic determinants of telomere length from 109,122 ancestrally diverse whole-genome sequences in TOPMed

Genetic studies on telomere length are important for understanding age-related diseases. Prior GWAS for leukocyte TL have been limited to European and Asian populations. Here, we report the first sequencing-based association study for TL across ancestrally-diverse individuals (European, African, Asian and Hispanic/Latino) from the NHLBI Trans-Omics for Precision Medicine (TOPMed) program. We used whole genome sequencing (WGS) of whole blood for variant genotype calling and the bioinformatic estimation of telomere length in n=109,122 individuals. We identified 59 sentinel variants (p-value OBFC1indicated the independent signals colocalized with cell-type specific eQTLs for OBFC1 (STN1). Using a multi-variant gene-based approach, we identified two genes newly implicated in telomere length, DCLRE1B (SNM1B) and PARN. In PheWAS, we demonstrated our TL polygenic trait scores (PTS) were associated with increased risk of cancer-related phenotypes

Two new diketopiperazines from the tin mine tailings-derived fungus <i>Schizophyllum commune</i> YIM DT 10058

<p>Two new diketopiperazines, named diphenylalazine C (<b>1</b>) and epicoccin U (<b>2</b>), together with six known compounds (<b>3</b>–<b>8</b>) were isolated from the EtOAc extract of the fermentation broth of the tin mine tailings-derived fungus <i>Schizophyllum commune</i> YIM DT 10058. Their structures were elucidated by detailed analysis of spectroscopic data and comparison with related known compounds. Compounds <b>1</b> and <b>2</b> exhibited weak antibacterial and cytotoxic activities.</p

ADAD2 interacts with RNF17 in P-bodies to repress the Ping-pong cycle in pachytene piRNA biogenesis

Pachytene piRNA biogenesis is a hallmark of the germline, distinct from another wave of pre-pachytene piRNA biogenesis with regard to the lack of a secondary amplification process known as the Ping-pong cycle. However, the underlying molecular mechanism and the venue for the suppression of the Ping-pong cycle remain elusive. Here, we showed that a testis-specific protein, ADAD2, interacts with a TDRD family member protein RNF17 and is associated with P-bodies. Importantly, ADAD2 directs RNF17 to repress Ping-pong activity in pachytene piRNA biogenesis. The P-body localization of RNF17 requires the intrinsically disordered domain of ADAD2. Deletion of Adad2 or Rnf17 causes the mislocalization of each other and subsequent Ping-pong activity derepression, secondary piRNAs overproduced, and disruption of P-body integrity at the meiotic stage, thereby leading to spermatogenesis arrested at the round spermatid stage. Collectively, by identifying the ADAD2-dependent mechanism, our study reveals a novel function of P-bodies in suppressing Ping-pong activity in pachytene piRNA biogenesis

A novel phenylspirodrimane dimer from cultures of the fungus <i>Stachybotrys chartarum</i>

<p>Stachartone A (<b>1</b>), a novel phenylspirodrimane dimer, was isolated from cultures of the tin mine tailings-associated fungus <i>Stachybotrys chartarum</i>. Its structure was elucidated by means of spectroscopic methods. At the same time, compound (<b>1</b>) was tested for its cytotoxicity against five human cancer cell lines.</p

A new cyclohexenone from the tin mine tailings-derived fungus <i>Aspergillus flavus</i> YIM DT 10012

<p>A new cyclohexenone, named phomaligol D (<b>1</b>), together with two known compounds, kojic acid (<b>2</b>) and phomaligol A (<b>3</b>) were isolated from the tin mine tailings-derived fungus <i>Aspergillus flavus</i> YIM DT 10012. Their structures were elucidated by detailed analysis of spectroscopic data.</p> <p>Structures of compounds <b>1</b>–<b>3</b> isolated from the cultures of <i>Aspergillus flavus</i> YIM DT 10012.</p